Teaching Activity 2017/2018

1. Pathophysiology of mitochondria: From energy conservation to disease pathogenesis and therapy, Prof. Paolo Bernardi

(5 lectures, May 7-11, 4:30-6:30 pm, room N mezzanine floor, Vallisneri Building)

1) The basic features of mitochondria and their function

2) The mechanism of energy conservation and its implications for cation transport (K+, Na+, and Ca2+)

3) Overview of the role of mitochondria in cell death

4) Critical assessment of the permeability transition and its role in disease pathogenesis

5) Recent progress in the mitochondrial therapy of muscular dystrophies


2. Astrocytes at the center of the brain of neurons, Dott. Piergiorgio Carmignoto

(5 lectures, May 14-18, 3:30-5:30 pm, room N mezzanine floor, Vallisneri Building)

1) Introduction to Glia

2) The tripartite synapse and gliotransmission

3) Gliotransmitters travel in time and space

4) Astrocytes as functional components of brain circuits

5) Astrocytes in brain disorders 


3. Neuromuscular plasticity with use, disuse and agein, Prof. Marco Narici

(5 lectures, April 9-13, seminar room 4th north floor 9.00-11:00 am on April 9,11,12,13, 11:00-13:00 am on April 10)

1) Skeletal Muscle: Structure and Function

2) Motor units and force generation

3) Neuromuscular adaptations with increased use

4) Neuromuscular adaptations with inactivity

5) Neuromuscular changes with ageing


 4. Development of Mitochondria-centered Treatments, Prof. Thomas Krieg

(5 lectures October 15-19)

Room will be assigned based on the number of participants.


 5. Post-translational modifications of proteins in cellular homeostasis and cancer, Dott. Stefano Ferrari

(5 lectures, June 4,6,7,8, 3.30-5:30 pm, room H mezzanine floor, Vallisneri Building, Jun 5 room I, 3.30-5:30 pm, mezzanine floor, Vallisneri Building)

1) Phosphorylation

2) Ubiquitylation/Sumoylation/Methods

3) PTMs & Cancer

4) PTMs hierarchy & crosstalk: the cell division cycle

5) PTMs hierarchy & crosstalk: the DNA damage response

6) Workshops


 6. Neurodegenerative diseases: Epidemiology, genetics and pathogenesis of brain misfolding diseases, Prof. Maria Pennuto

(5 lectures, May 7-11, seminar room 2nd north floor 9:00-11:00 am on May 7,9,10,11, 11:00-13:00 am on May 8)

1) Principles of neurodegeneration

2) Alzheimer disease: clinical aspects, pathology, genetics

3) Parkinson disease: clinical aspects, pathology, genetics

4) Repeat expansion disorders: Loss of function, RNA-mediated gain of function andprotein-mediated gain of function, Polyglutamine diseases

5) The genetics of ALS: Focus of RNA- and protein-mediated motor neuron degeneration


7. Introduction to structural crystallography and diffraction

(40 hours, June 4-8, Department of Geosciences, Via Gradenigo 6)

Methods based on the use of X-rays for the analysis of molecules and materials, with particular emphasis on X-ray diffraction.


8. Understanding protein dynamics with computational methods

(12 hours Prof. Silvio Tosatto, Prof. Gustavo Parisi- Universidad Nacional de Quilmes -Argentina, Prof. Sebastian Fernandez Alberti- Universidad Nacional de Quilmes -Argentina. September 26-27-28, 15:00-18:30, Seminar room 5th east floor)

1) Order and disorder in proteins (Prof. Silvio Tosatto)

2) Protein conformational diversity (Prof. Gustavo Parisi)

3) Protein dynamics and function (Prof. Sebastian Fernandez Alberti)