1. Prof. Paolo Bernardi - Pathophysiology of mitochondria: From energy conservation to disease pathogenesis and therapy (5 lectures)
1. The basic features of mitochondria and their function
2. The mechanism of energy conservation and its implications for cation transport (K+, Na+, and Ca2+)
3. Overview of the role of mitochondria in cell death
4. Critical assessment of the permeability transition and its role in disease pathogenesis
5. Recent progress in the mitochondrial therapy of muscular dystrophies
2. Prof. Silvio Tosatto - Protein bioinformatics (5 lectures)
Introductory course to the use of comptutational resources, databases and tools, to analyze protein sequences and structures. Topics for lectures include: (1) sequence similarity and molecular evolution, (2) prediction of structural features from sequence, (3) protein structure and modeling, (4) protein function and interactions. The lectures will be complemented by hands-on practical sessions demonstrating the use of online resources.
3. Dr. Piergiorgio Carmignoto - A visual voyage into the brain: advanced imaging technologies lead to new concept of brain functions (5 lectures)
The course will start presenting pioneering findings on the physiology of neurons and how our view of brain function and of the cellular mechanisms at the basis of information processing in the brain has changed in the history of neuroscience. The contributions of Ramon Y Cajal and Camillo Golgi to the foundation of neuroscience will be recognized. The course will then focus on advanced optical methodologies, such as single/two-photon laser microscopy and optogenetics coupled with electrophysiological recordings of neuronal activity, and discuss how this new approach has provided fundamental insights into the specificialized role in brain function of distinct subpopulations of neurons and interneurons. Finally, extensively discussed will be the most recent findings that by revealing how astrocytes can weaken or strenghten neuron-to-neuron communication herald a shifting paradigm in neuroscience.
4. Prof. Michael Eldar - Electrophysiology of electrical primary diseases (10 lectures)
1. The Long QT syndrome
2. Brugada Syndrome
4. The short QT syndrome
5. Early repolarization syndrome
5. Prof. Aram Megighian - Introduction to basic clinical aspects of neurological and psychiatric diseases (5 lectures)
1. Nervous system as an integrated neuronal system: neurons, synapses, circuits, and behavior. Electrical activity, coding, and functional Areas
2. Cardinal manifestations of neurological disease. A) Disorders of motility; disorders of sensation (somatic and proprioceptive); disorders of special senses
3. Cardinal manifestations of neurological disease. B) Epilespy, consciousness, sleep
4. Derangement of intellect and behavior. Anxiety and mood. Memory
5. Are “schizophrenic mice” suffering delusions? What should we search in an animal model of a neuro-psychiatric disorder?
6. Prof. Barbara Zavan - Stem cells and regenerative medicine (5 lectures)
1. Stem cell: definition, biology, metabolism
2. Protocol to isolate Stem cell from different tissues: bone marrow, adipose tissue, dental pulp, skin
3. Protocol to culture, expansion, characterization, seeding onto biomaterial of Stem cell
4. Biomaterials for muscle regeneration
5. Biomaterials for neuronal tissue regeneration
Neurobiology, Prof. Daniela Pietrobon, Second Cycle-degree in Molecular Biology, I year, II semester.
From February 27th to June 9th (Room will be assigned at a later date, check the website)