Courses a.a. 2021/2022

1. Cell Ca2+ signalling: pathways, regulation and tools

10 hours, 16:00-17:30

1) 22/11, Prof. Tullio Pozzan, room RH Vallisneri 16:00-17:30
2) 23/11, Dott. Elisa Greotti, room RH Vallisneri 16:00-17:30
3) 29/11, Dott. Diana Pendin, room RH Vallisneri 16:00-17:30
4) 30/11, Dott. Emy Basso and Nelly Redolfi, room RH Vallisneri 16:00-17:30
5) 01/12, Dott. Riccardo Filadi, room RN Vallisneri 16:00-17:30

2. Refreshing memories of metabolic pathways

10 hours, Prof. Fabio Di Lisa


3. Prof. Paolo Bernardi, Pathophysiology of mitochondria: From energy conservation to disease pathogenesis and therapy

10 hours, Prof. Paolo Bernardi

July 4,5,6,7,8 16:00-18:00 seminar room 1th north floor Vallisneri

1) The basic features of mitochondria and their function
2) The mechanism of energy conservation and its implications for cation transport (K+, Na+, and Ca2+)
3) Overview of the role of mitochondria in cell death
4) Critical assessment of the permeability transition and its role in disease pathogenesis
5) Recent progress in the mitochondrial therapy of muscular dystrophies

4. A journey with the cytotoxic lymphocytes

10 hours, Prof. Denis Martinvalet

May 23,24,25,27,30: 16:00-18:00 seminar room 1th north floor Vallisneri

1) Self and Non-self for the cytotoxic lymphocytes: A general introduction to basic immunology.
2) Cytotoxic lymphocytes in the body: Histology of the lymphoid tissues.
3) Development, function and pathology of cytotoxic lymphocytes.
4) Mechanisms of lymphocyte cytotoxicity.
5) Cytotoxic lymphocytes in the clinic.

5. Neuromuscular plasticity

10 hours, Prof. Marco Narici

May 9,10,11,13,16 16:00-18:00 seminar room 1th north floor Vallisneri

1) Skeletal Muscle: Structure and Function
2) Motor units and force generation
3) Neuromuscular adaptations with increased use
4) Neuromuscular adaptations with inactivity
5) Neuromuscular changes with ageing

6. Post-translation modifications of proteins (PTMs): how to survive in a dense forest

10 hours, Proff. Maria Ruzzene, Mauro Salvi, Christian Borgo:

June 15, 17, 27, 28, 29 16:00-18:00 seminar room 1th north floor Vallisneri

1. PTMs: an overview
2. Protein phosphorylation: how, when, why
3. How to modulate PTMs by using inhibitors and activators
4. Phospho-site identification and characterization
5. Workshop: see if PTMs are involved in your research at all. Practical cases proposed by the students

7. Astrocytes at the center of the brain of neurons

10 hours, Dott. Pie Giorgio Carmignoto


8. Neurodegenerative diseases: Epidemiology, genetics and pathogenesis of brain misfolding diseases

10 hours, Prof. Prof. Maria Pennuto

June 6,7,8,10,14 15:30-17:00 seminar room 1th north floor Vallisneri

1) Principles of neurodegeneration
2) Alzheimer disease: clinical aspects, pathology, genetics
3) Parkinson disease: clinical aspects, pathology, genetics
4) Repeat expansion disorders: Loss of function, RNA-mediated gain of function andprotein-mediated gain of function, Polyglutamine diseases
5) The genetics of ALS: Focus of RNA- and protein-mediated motor neuron degeneration

9. Regeneration of skeletal muscle: from biology to physiopathology

10 hours, Prof. Pompeo Volpe

September 23,26,27,28,30 16:00-18:00 seminar room 1th north floor Vallisneri

1) Regeneration of skeletal muscle: not always and not forever
2) The undisputed star: the satellite cell
3) Myogenesis: from myoblasts to myofibers.
4) The Duchenne muscular distrophy: physiopathology and the regenerative approach
5) The Studiskji’s approach and the heterochronic parabiosis for (future) skeletal muscle regeneration: always and forever

10.Epigenomics and transcriptomics: from theory to practice

10 hours, Prof. Marco Giorgio, Dott.ssa Francesca Casciaro e Dott. Giuseppe Persico

room 0B and 2C Botta Building, Lab36 and Lab140 Paolotti:
March 30  15:30-17:30 room 0B Botta
April 6 15:30-18:30 Lab36 Paolotti
April 20 15:30-17:30 room 2C Botta
April 27 15:30-18:30 Lab140 Paolotti
May 4 15:30-17:30  room 2C Botta

1) RNA-seq, transcriptome analysis

2) Bioinformatic analysis of RNA-seq data

3) Chromatin immunoprecipitation protocols

4) Bioinformatic analysis of ChiP-seq data

5) Genomic adaptation to aging and environment



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